Does PrEP work differently for “tops” or “bottoms”?

Bottoms are already at much greater risk for HIV than tops. One of the great things about Truvada for PrEP is that the drugs are known to be very good at protecting people from infection during receptive anal intercourse. After you swallow the pill and Truvada is absorbed into your body, much of it winds up in your colorectal tissue—ready to fight any HIV that it encounters. That doesn’t mean that PrEP isn’t a good prevention option for tops—it just means it has even greater benefits for bottoms.