Other anti-HIV drugs are also currently being studied for PrEP, to provide a wider array of options. They have not yet been shown to be effective for PrEP, nor have they been FDA approved. However, trials are currently underway to determine if they are effective and in a few years we will know more. These drugs include:
MARAVIROC (also called Selzentry or MVC):
This medication is taken as a once-daily oral pill and works by blocking entry of HIV into the body’s cells.
RILPIVIRINE (also known as Edurant):
This medication is injected once a month as a long-acting formulation and works by blocking an enzyme called HIV reverse transcriptase. By blocking this enzyme, it prevents HIV from making more copies of itself in the body.
DAPIVIRINE (also known as TMC120):
This medication is released by a vaginal ring that is worn for four weeks at a time. The medication works by binding to and disabling an enzyme called HIV reverse transcriptase. By disabling this enzyme, it prevents HIV from making more copies of itself in the body.
TENOFOVIR (also known as tenofovir disoproxyl fumarate, TDF, or Viread):
This medication is one part of the already approved combination pill Truvada. By itself, it is currently being studied as part of a microbicide gel to be inserted rectally and/or vaginally. Tenofovir works by blocking an enzyme called HIV reverse transcriptase. By blocking this enzyme, it prevents HIV from making more copies of itself in the body.