For the first few weeks of starting Truvada for PrEP, some people complain about nausea, vomiting, fatigue, and dizziness, with these minor symptoms eventually resolving themselves over time.
Some people in clinical trials had elevations in blood tests that looked at kidney function. With this particular side effect, there were no physical symptoms, so it is important to remember that if you take PrEP, you need to get routinely checked by your doctor to make sure your kidneys are working properly.
Some people in studies had a decrease in bone mineral density within the first month. However, but these changes were small, did not progress over time, and did not increase risk for fracture. Once Truvada was stopped, the bone mineral density returned to normal.